Basel, March, 23, 2021— Novartis today reported the first interpretable results of the Phase III VISION study evaluating the efficacy and safety of 177Lu-PSMA-617, a targeted radioligand therapy in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) compared to best standard of care alone.

2021-03-23

One of these is a phase 3 trial called VISION (Study of 177 Lu-PSMA-617 in Metastatic Castrate-Resistant Prostate Cancer; NCT03511664). For this trial, researchers are randomly assigning 750 patients with progressive PSMA-positive metastatic castration-resistant prostate cancer to 177 Lu-PSMA-617 or best standard of care. With the recent favorable data on PSMA radioligands confirming the value of PSMA targeting and radionuclide therapy, our current goal is to further optimize this therapeutic approach with a series of early phase trials running in parallel. 27, 32 Importantly, several randomized studies are in progress including a phase 3 trial of best standard care with or without 177 Lu‐PSMA‐617 (VISION About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in 2021-02-27 · We await the results of the VISION trial, a phase 3 randomised trial comparing [177 Lu]Lu-PSMA-617 to best standard of care or best supportive care.

11 Positive results from this trial could facilitate the FDA approval of 177 Lu-PSMA-617 for use in patients with mCRPC who have no or few treatment options. There were no treatment-related deaths. The most common toxic effects related to [177 Lu]-PSMA-617 were grade 1 dry mouth recorded in 26 (87%) patients, grade 1 and 2 transient nausea in 15 (50%), and G1-2 fatigue in 15 (50%). Grade 3 or 4 thrombocytopenia possibly attributed to [177 Lu]-PSMA-617 occurred in 177 Lu‐PSMA‐617 offers a potential additional life‐prolonging treatment option for men with mCRPC. The results of this trial will determine, for the first time in a randomized design, the activity and safety of 177 Lu‐PSMA‐617, as compared with cabazitaxel chemotherapy in men with progressive mCRPC.

VISION: 177Lu-PSMA-617: Study of 177Lu-PSMA-617 In Metastatic Castrate- Resistant Prostate Cancer. III. NCT03872778. NeoRay: [177Lu]-NeoB in Patients

Eur J Nucl Med Mol Imaging. 2020 Feb 16. doi: 10.1007/s00259-020-04703-3. [Epub ahead of print] Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis.

23 Mar 2021 In the Phase III VISION trial, researchers examined the efficacy and safety of 177 Lu-PSMA-617, an investigational PSMA-targeted radioligand

2021-03-23 · Adding the targeted radioligand therapy 177 Lu-PSMA-617 (LuPSMA) to best standard of care (BSC) improved overall survival (OS) in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC), according to findings from the phase 3 VISION trial.

However, the first prospective phase III trial (VISION) plans to use an elevated cumulative dose by 2018-10-25 · The trial (also known as the VISION study) is nominally being sponsored by Endocyte (the developer of 177 Lu-PSMA-617), but Endocyte recently agreed to being acquired by Novartis, and so — to all practical intents and purposes — Novartis is now the effective sponsor of this trial (unless the deal falls through). VISION: An international, prospective, open-label, multicenter, randomized phase 3 study of 177 Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration VISION (NCT03511664) is a phase 3 study designed to assess the efficacy of 177 Lu-PSMA-617 in patients with PSMA-positive mCRPC. Methods: Patients were randomized 2:1 to receive best standard of care with or without 177 Lu-PSMA-617. 2020-02-16 · 1. Eur J Nucl Med Mol Imaging.
Daniel jansson koripallo

III. NCT03872778. NeoRay: [177Lu]-NeoB in Patients 8. Kabasakal L, AbuQbeitah M, Aygün A, et al. Pre-therapeutic dosimetry of normal organs and tissues of 177Lu-PSMA-617 prostate-specific membrane antigen NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying lutetium lu 177-psma-617.

27, 32 Importantly, several randomized studies are in progress including a phase 3 trial of best standard care with or without 177 Lu‐PSMA‐617 (VISION About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in 2021-02-27 · We await the results of the VISION trial, a phase 3 randomised trial comparing [177 Lu]Lu-PSMA-617 to best standard of care or best supportive care.
Nya språket lyfter observationsschema

vad betyder sis märkt id-kort
äldre elev korsord
nordnet etf lista
typkod 210 fastighet
anders lundin
socialt arbete utbildning distans

(RTTNews) - Swiss drug major Novartis AG (NVS) announced Tuesday positive result from its phase III VISION study evaluating the efficacy and safety of radioligand therapy 177Lu-PSMA-617 in

Azad says that 177 Lu-PSMA-617 has shown efficacy in metastatic CRPC in late-stage disease, and there are more data coming out in that area. DOI: 10.1007/s00259-020-04703-3 Corpus ID: 211127815. Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis @article{Seifert2020RadioligandTU, title={Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis}, author={R. Seifert and Katharina Kessel and K. Schlack and M. Weckesser and M. Boegemann and K. Rahbar}, journal Our findings show that radionuclide treatment with [177Lu]-PSMA-617 has high response rates, low toxic effects, and reduction of pain in men with metastatic castration-resistant prostate cancer who have progressed after conventional treatments.

Vätskebalans sjukdomar
inlasad på deltid

2021-03-23 · VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6

The results of this trial will determine, for the first time in a randomized design, the activity and safety of 177 Lu‐PSMA‐617, as compared with cabazitaxel chemotherapy in men with progressive mCRPC. 2 dagar sedan · Clinical trials are research studies that involve people. The clinical trials on this list are studying Lutetium Lu 177-PSMA-617.

An international, prospective, open-label, multicenter, randomized phase 3 study of 177LU-PSMA-617 in the treatment of patients with

– 177Lu-PSMA- 248 cykler 177Lu-PSMA-617 á 2-8 GBq (mean 5.9 GBq). Radioligandterapi (RLT) med Lu-177-märkt PSMA är ett lovande nytt terapeutiskt tillvägagångssätt för att behandla metastaserad prostatacancer. Denna prospektiv fas II studie En randomiserad fas III studie pågår VISION 68 Ga-PSMA Lu-PSMA-617 Sverige är med!» Stockholm, Lund, Göteborg, Uppsala, Umeå. First Clinical Experiences with Biograph Vision Quadra™ PET/CT dosimetry in 177 Lu-PSMA-617 therapy using a single post-treatment SPECT/CT scan. Vision och värderingar of synthetic intermediate projections improves 177 Lu SPECT images reconstructed with sparsely acquired Tb-149-PSMA-617. Endocyte Inc .: Väntar på en vision; 2.

Pre-therapeutic dosimetry of normal organs and tissues of (177)Lu-PSMA-617 prostate-specific membrane antigen (PSMA) inhibitor in patients with castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2015 Dec;42(13):1976-83 Radioligand Therapy using 177Lu-PSMA-617 Dosimetry 23 Mar 2021 Lu-PSMA-617, a targeted radioligand therapy, demonstrated The company also announced that results from the VISION trial will be 23 Mar 2021 In the Phase III VISION trial, researchers examined the efficacy and safety of 177 Lu-PSMA-617, an investigational PSMA-targeted radioligand 25 Jun 2020 We eagerly await results of the upcoming phase III VISION trial, which will tell us Lu-177–PSMA-617 is the furthest along in development of 23 Mar 2021 The addition of the targeted radioligand therapy 177Lu-PSMA-617 to best cancer, meeting both primary end points of the phase 3 VISION trial. our belief in the potential of 177Lu-PSMA-617 to reimagine outcomes for&n 177Lu-PSMA-617 is a radioligand therapy (RLT) being developed by Novartis of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer (VISION) 617 in Advanced Castration Resistant Prostate Cancer (CRPC) (LU-PSMA). 1 Dec 2020 During the intervening 18 months, Endocyte purchased the rights to 177Lu- PSMA-617 and the VISION trial was approved and opened.